Description

tert-Butyl 5-Carbamoylisoindoline-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its isoindoline core and protected carboxylate group. This compound is of significant value in medicinal chemistry for the synthesis of complex bioactive molecules, particularly those targeting neurological and oncological pathways. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those with isoindoline-based structures.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of linker molecules and warhead components for targeted protein degradation therapies.
• Kinase Inhibitor Synthesis: Serves as a precursor in the manufacture of small molecule inhibitors for various kinase targets.
• Chemical Biology Research: Employed as a tool compound for studying enzyme function and protein-ligand interactions.
• Peptidomimetic Chemistry: Utilized to introduce constrained, heterocyclic scaffolds into peptide analogs to enhance stability and bioavailability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.

Basic Information

Product Name	tert-Butyl 5-Carbamoylisoindoline-2-Carboxylate
CAS No.	685565-18-8
Molecular Formula	C₁₄H₁₈N₂O₃
Molecular Weight	262.31 g/mol
Synonyms	2-Isoindolinecarboxylic acid, 5-carbamoyl-, 1,1-dimethylethyl ester; 5-Carbamoylisoindoline-2-carboxylic acid tert-butyl ester; tert-Butyl 5-carbamoyl-2,3-dihydro-1H-isoindole-2-carboxylate; 1,1-Dimethylethyl 5-(aminocarbonyl)-2,3-dihydro-1H-isoindole-2-carboxylate; 2-(tert-Butoxycarbonyl)-5-carbamoylisoindoline; Boc-5-carbamoylisoindoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Carbamoylisoindoline-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Specifications are aligned with the requirements for advanced pharmaceutical intermediates, supporting both research and pre-clinical development stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.