Description

2-(3,5-Difluorophenyl)-1,3,2-Dioxaborinane is a high-purity, cyclic boronic ester derivative, a crucial building block in modern synthetic chemistry. Its value lies in its role as a protected boronic acid, offering enhanced stability and handling characteristics for complex cross-coupling reactions. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing complex, fluorinated biaryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that incorporate difluorophenyl motifs for enhanced efficacy and environmental profile.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Probe Development: Employed in the synthesis of fluorinated molecular probes and tags for imaging, diagnostics, and studying biological mechanisms.
• Process Chemistry & Scale-up: Provides a stable, crystalline form of the boronic acid functionality for reliable and scalable manufacturing processes in fine chemical production.

Basic Information

Product Name	2-(3,5-Difluorophenyl)-1,3,2-Dioxaborinane
CAS No.	684648-47-3
Molecular Formula	C9H9BF2O2
Molecular Weight	197.98 g/mol
Synonyms	2-(3,5-Difluorophenyl)-1,3,2-dioxaborinane; 3,5-Difluorophenyl-1,3,2-dioxaborinane; 1,3,2-Dioxaborinane, 2-(3,5-difluorophenyl)-; (3,5-Difluorophenyl)boronic acid 1,3-propanediol ester; 5,5-Difluoro-1,3,2-benzodioxaborole (incorrect but common misnomer); 3,5-Difluorophenylboronic acid cyclic propane-1,3-diyl ester; B-(3,5-Difluorophenyl)-1,3,2-dioxaborinane
EINECS	Contact for details

Quality Control

Our 2-(3,5-Difluorophenyl)-1,3,2-Dioxaborinane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing lot-specific results are provided to guarantee consistency and traceability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.