Description

3-Chlorophenylboronic Acid-1,3-Propanediol Ester is a protected boronic acid derivative, offering enhanced stability and handling characteristics compared to its free acid counterpart. This compound is a crucial synthetic intermediate, valued for its role in facilitating Suzuki-Miyaura cross-coupling reactions to construct complex biaryl structures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the efficient synthesis of novel compounds and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific biphenyl or heterobiaryl scaffolds.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysts, and functionalized polymers.
• Chemical Biology & Medicinal Chemistry: Serves as a versatile reagent for constructing molecular probes and libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: A critical reagent for fine chemical producers specializing in bespoke, multi-step organic synthesis for client projects.

Basic Information

Product Name	3-Chlorophenylboronic Acid-1,3-Propanediol Ester
CAS No.	684648-44-0
Molecular Formula	C9H12BClO3
Molecular Weight	214.45 g/mol
Synonyms	3-Chlorophenylboronic acid 1,3-propanediol ester; (3-Chlorophenyl)-4,6,8-trioxa-5-borabicyclo[3.3.0]octane; 5-(3-Chlorophenyl)-4,6,8-trioxa-5-borabicyclo[3.3.0]octane; 3-Chlorobenzeneboronic acid 1,3-propanediol cyclic ester; m-Chlorophenylboronic acid pinacol ester analog; B-(3-Chlorophenyl)-4,6,8-trioxa-5-borabicyclo[3.3.0]octane; 3-Chloro phenyl boronic acid propane diol ester
EINECS	Contact for details

Quality Control

Our 3-Chlorophenylboronic Acid-1,3-Propanediol Ester is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical specifications are available upon request, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air and moisture must be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.