Description

4-Trifluoromethylcyclohex-1-Enyl-1-Boronic Acid Pinacol Ester CAS NO 683242-93-5 is a high-value, advanced boronic ester building block designed for sophisticated organic synthesis. Its core value lies in enabling the precise introduction of a functionalized cyclohexenyl moiety via robust cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, where the trifluoromethyl group is prized for its ability to modulate lipophilicity, metabolic stability, and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex drug candidates, particularly in the synthesis of molecules containing fluorinated, saturated, and unsaturated carbocyclic systems.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides that benefit from the unique properties of the trifluoromethyl group.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, liquid crystals, and polymers with tailored properties.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds with high efficiency and selectivity.
• Medicinal Chemistry Library Development: Enables the rapid generation of diverse compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Fluorine Chemistry: An important reagent for studying the effects of fluorine substitution in organic molecules, aiding in the design of compounds with improved stability and performance.

Basic Information

Product Name	4-Trifluoromethylcyclohex-1-Enyl-1-Boronic Acid Pinacol Ester
CAS No.	683242-93-5
Molecular Formula	C₁₃H₂₀BF₃O₂
Molecular Weight	276.11 g/mol
Synonyms	4-(Trifluoromethyl)cyclohex-1-ene-1-boronic acid pinacol ester; 1-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)cyclohex-1-ene; 4-(Trifluoromethyl)-1-cyclohexen-1-ylboronic acid pinacol ester; 4-Trifluoromethyl-1-cyclohexenylboronic acid pinacol ester; 4-Trifluoromethyl-1-cyclohexen-1-ylboronic acid, pinacol ester; (4-Trifluoromethylcyclohex-1-en-1-yl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[4-(trifluoromethyl)cyclohex-1-en-1-yl]-1,3,2-dioxaborolane
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Quality Control

Our 4-Trifluoromethylcyclohex-1-Enyl-1-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹⁹F, ¹¹B) and HPLC analysis, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.