Description

1-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is a high-value, protected boronic ester derivative of indole, serving as a critical synthetic intermediate. Its primary value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable building blocks for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for indole-based compounds with potential therapeutic applications.
• Agrochemical Synthesis: Used in the research and development of new crop protection agents and herbicides, leveraging its boronic ester functionality for structural diversification.
• Organic Light-Emitting Diodes (OLEDs): Serves as a building block for creating advanced organic electronic materials and emissive layers in display technologies.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Academic and R&D Laboratories: A valuable reagent for methodological development in organic chemistry and for constructing complex heterocyclic scaffolds in discovery research.
• Material Science: Utilized in the synthesis of polymers and functional materials where the indole moiety imparts specific electronic or photophysical properties.

Basic Information

Product Name	1-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole
CAS No.	683229-61-0
Molecular Formula	C15H20BNO2
Molecular Weight	257.14 g/mol
Synonyms	1-Methyl-1H-indol-3-ylboronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-indole; 1-Methylindole-3-boronic acid pinacol ester; N-Methyl-3-boronoindole pinacol ester; 1-Methyl-3-(pinacolatoboryl)-1H-indole; 1-Methyl-3-indolylboronic acid pinacol ester; 683229-61-0; 1-Methyl-3-(4,4,5,5-tetramethyl-2-dioxa-3-borinan-2-yl)-1H-indole
EINECS	Contact for details

Quality Control

Our 1-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant regulatory frameworks, and specifications can be aligned with cGMP standards for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.