Description

4-Isoxazolecarboxylic Acid, 3-(2-Chlorophenyl)-5-(Hydroxymethyl)- is a high-value, multifunctional heterocyclic building block featuring a carboxylic acid group, a hydroxymethyl substituent, and a chlorophenyl ring. This unique structure makes it a critical intermediate for the synthesis of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals, where precise molecular architecture is paramount. It is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Serves as a versatile precursor for creating novel herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Ligand and Catalyst Development: Used in organometallic chemistry to synthesize chelating ligands for catalysis or metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of advanced polymers and functional materials due to its reactive functional groups.
• Chemical Biology Probes: Utilized to create molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis and Contract Manufacturing: A fundamental building block for custom synthesis services catering to client-specific molecular targets.

Basic Information

Product Name	4-Isoxazolecarboxylic Acid, 3-(2-Chlorophenyl)-5-(Hydroxymethyl)-
CAS No.	682353-00-0
Molecular Formula	C11H8ClNO4
Molecular Weight	253.64 g/mol
Synonyms	3-(2-Chlorophenyl)-5-(hydroxymethyl)isoxazole-4-carboxylic acid; 3-(2-Chlorophenyl)-5-(hydroxymethyl)-1,2-oxazole-4-carboxylic acid; 4-Carboxy-3-(2-chlorophenyl)-5-hydroxymethylisoxazole; 682353-00-0; 4-Isoxazolecarboxylic acid, 3-(2-chlorophenyl)-5-(hydroxymethyl)-; 3-(2-Chlorophenyl)-5-(hydroxymethyl)-4-isoxazolecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of 4-Isoxazolecarboxylic Acid, 3-(2-Chlorophenyl)-5-(Hydroxymethyl)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting cGMP-compliant development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.