Description

4-(4-Trifluoromethoxybenzoyl)-Piperidine is a high-purity, advanced pharmaceutical intermediate characterized by its distinct trifluoromethoxy-substituted benzoylpiperidine structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique trifluoromethoxy pharmacophore.
• API Development: Serves as a precursor in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.
• Biochemical Tool Compound: May be used in the development of biochemical probes for target validation and assay development.
• Academic Research: Employed in university and institutional labs for exploratory organic synthesis and drug discovery projects.

Basic Information

Product Name	4-(4-Trifluoromethoxybenzoyl)-Piperidine
CAS No.	681482-56-4
Molecular Formula	C13H14F3NO2
Molecular Weight	273.25 g/mol
Synonyms	4-(4-(Trifluoromethoxy)benzoyl)piperidine; 1-[4-(Trifluoromethoxy)benzoyl]piperidine; 4-(4-Trifluoromethoxy-benzoyl)-piperidine; Piperidine, 4-[4-(trifluoromethoxy)benzoyl]-; 4-(α-Oxo-4-(trifluoromethoxy)benzyl)piperidine
EINECS	Contact for details

Quality Control

Our 4-(4-Trifluoromethoxybenzoyl)-Piperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, and custom purity grades are available to support specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider the use of a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.