Description

Cyclopentaneacetic Acid, -α-,-α--Difluoro-1-Hydroxy- (9Ci) is a high-value, fluorinated organic building block characterized by its cyclopentane backbone and difluoro-hydroxy-acetic acid moiety. This compound matters as a sophisticated chiral synthon, enabling the precise introduction of fluorine atoms and specific stereochemistry into target molecules, which is critical for modulating their biological activity and metabolic stability. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, particularly in the development of protease inhibitors, receptor modulators, and other fluorinated bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), especially in antiviral and anticancer drug discovery.
• Agrochemical Synthesis: Used in the research and development of advanced fluorinated pesticides and herbicides, where fluorine substitution enhances efficacy and environmental persistence.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to optimize the potency and pharmacokinetic properties of lead compounds.
• Fluorine Chemistry: An important reagent for academic and industrial research focused on developing new fluorination methodologies and studying fluorine's unique effects.
• Peptidomimetic Development: Utilized in the design and synthesis of fluorinated peptide analogs and protease inhibitors.
• Material Science Precursor: Potential use as a specialty monomer or additive for creating fluorinated polymers with specific surface properties.

Basic Information

Product Name	Cyclopentaneacetic Acid, -α-,-α--Difluoro-1-Hydroxy- (9Ci)
CAS No.	681240-10-8
Molecular Formula	C7H10F2O3
Molecular Weight	180.15 g/mol
Synonyms	2,2-Difluoro-2-hydroxy-1-cyclopentylacetic Acid; 1-Cyclopentyl-2,2-difluoro-2-hydroxyethanoic Acid; α,α-Difluoro-α-hydroxycyclopentaneacetic Acid; (1-Cyclopentyl-2,2-difluoro-2-hydroxy)acetic Acid; 681240-10-8; Cyclopentyl(difluoro)glycolic Acid
EINECS	Contact for details

Quality Control

Our Cyclopentaneacetic Acid, -α-,-α--Difluoro-1-Hydroxy- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the exacting standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.