Description

Bicyclo[2.2.1]Heptane-2-Methanol, 3-(Trifluoromethyl)- (9Ci) is a specialized fluorinated norbornane derivative, serving as a high-value chiral building block and intermediate in advanced organic synthesis. Its unique rigid bicyclic framework combined with the trifluoromethyl and hydroxymethyl functional groups makes it a critical precursor for developing novel pharmaceuticals and agrochemicals with enhanced metabolic stability and bioavailability. This compound is essential for researchers and process chemists in pharmaceutical R&D, agrochemical discovery, and materials science, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a backbone for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Advanced Material Precursor: Employed in the research and development of specialty polymers and liquid crystals with unique thermal and optical properties.
• Chemical Biology Probe: Utilized as a molecular scaffold in probe design for studying enzyme mechanisms and protein-ligand interactions.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research exploring the effects of fluorination on molecular conformation and reactivity.

Basic Information

Product Name	Bicyclo[2.2.1]Heptane-2-Methanol, 3-(Trifluoromethyl)- (9Ci)
CAS No.	681220-36-0
Molecular Formula	C9H13F3O
Molecular Weight	194.20 g/mol
Synonyms	3-(Trifluoromethyl)bicyclo[2.2.1]heptane-2-methanol; 2-Norbornanemethanol, 3-(trifluoromethyl)-; 3-(Trifluoromethyl)-2-norbornanemethanol; (1R,2S,3R,4S)-3-(Trifluoromethyl)bicyclo[2.2.1]heptane-2-methanol; (1S,2R,3S,4R)-3-(Trifluoromethyl)bicyclo[2.2.1]heptane-2-methanol; endo-3-(Trifluoromethyl)-2-norbornanemethanol; exo-3-(Trifluoromethyl)-2-norbornanemethanol
EINECS	Contact for details

Quality Control

Our Bicyclo[2.2.1]Heptane-2-Methanol, 3-(Trifluoromethyl)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development projects with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Chiral Purity (Chiral HPLC)	≥99.0% ee (for enantiopure grades)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.