Description

3-Furancarboxylicacid,Tetrahydro-2-Methyl-5-Oxo-,Methylester,(2R,3R)-Rel- is a high-purity chiral building block and advanced pharmaceutical intermediate. Its defined stereochemistry and functionalized tetrahydrofuran core make it a critical synthon for the asymmetric synthesis of complex bioactive molecules. This compound is primarily needed by pharmaceutical R&D and fine chemical synthesis teams developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drugs.
• Asymmetric Synthesis: Serves as a building block for constructing complex, stereodefined molecular architectures in medicinal chemistry.
• Organic Synthesis Research: Used in academic and industrial laboratories for method development and the exploration of new synthetic pathways.
• Fine Chemical Production: Intermediate in the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Catalyst and Ligand Development: Potential precursor for novel chiral catalysts and ligands used in enantioselective transformations.

Basic Information

Product Name	3-Furancarboxylicacid,Tetrahydro-2-Methyl-5-Oxo-,Methylester,(2R,3R)-Rel-
CAS No.	681179-34-0
Molecular Formula	C8H12O4
Molecular Weight	172.18 g/mol
Synonyms	(2R,3R)-rel-2-Methyl-5-oxotetrahydrofuran-3-carboxylic acid methyl ester; Methyl (2R,3R)-rel-2-methyl-5-oxooxolane-3-carboxylate; Methyl 2-methyl-5-oxotetrahydrofuran-3-carboxylate (rel-(2R,3R)-form); Tetrahydro-2-methyl-5-oxo-3-furancarboxylic acid methyl ester, (2R,3R)-rel-; 3-Furancarboxylic acid, tetrahydro-2-methyl-5-oxo-, methyl ester, (2R,3R)-rel-; Chiral tetrahydrofuran ester; 2-Methyl-5-oxotetrahydrofuran-3-carboxylic acid methyl ester (racemic diastereomer).
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric/diastereomeric purity. Quality is verified through advanced analytical techniques including HPLC, GC, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Diastereomeric Excess (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.