Description

1-Bromo-3-(1,3-Dioxolan-2-Yl)-4-Fluorobenzene is a high-value, multi-functional aromatic building block designed for advanced synthetic chemistry. This compound is strategically engineered to serve as a key intermediate in the synthesis of complex molecules, offering precise reactivity for selective functionalization. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the fluorine atom and bromine handle enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for creating fluorinated and heterocyclic components in electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form complex biaryl structures.
• Functional Polymer Monomer: Employed in the development of specialty polymers with tailored thermal, optical, or electronic properties.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	1-Bromo-3-(1,3-Dioxolan-2-Yl)-4-Fluorobenzene
CAS No.	679840-30-3
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	2-(2-Bromo-5-fluorophenyl)-1,3-dioxolane; 4-Fluoro-3-(1,3-dioxolan-2-yl)bromobenzene; 2-Bromo-5-fluoro-1,3-benzodioxole (incorrect but common misnomer); 5-Bromo-2-fluorobenzaldehyde ethylene acetal; Benzene, 1-bromo-3-(1,3-dioxolan-2-yl)-4-fluoro-; 3-Bromo-6-fluorobenzaldehyde ethylene acetal
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-(1,3-Dioxolan-2-Yl)-4-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.