Description

1,5-Dibromo-2,4-difluoro-3-iodobenzene is a highly functionalized halogenated benzene derivative, serving as a critical multi-halogenated synthon for advanced organic synthesis. Its precise substitution pattern makes it an invaluable building block for constructing complex molecules where specific halogen atoms are required for subsequent cross-coupling or nucleophilic substitution reactions. This compound is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those requiring halogenated aromatic cores for bioactivity or further functionalization.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and pesticides where the specific halogen atoms influence the compound's biological activity and environmental properties.
• Material Science Research: Serves as a monomer or building block for creating halogenated polymers, liquid crystals, or organic electronic materials with tailored properties.
• Cross-Coupling Reactions: The iodine and bromine atoms provide distinct reactivity for selective Suzuki, Stille, or Sonogashira cross-coupling reactions to form biaryl or extended conjugated systems.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for metal catalysis or as a scaffold for catalyst design.
• Fluorinated Compound Libraries: An essential starting material for generating libraries of fluorinated compounds in medicinal chemistry for ADMET optimization.

Basic Information

Product Name	1,5-Dibromo-2,4-difluoro-3-iodobenzene
CAS No.	679836-60-3
Molecular Formula	C6HBr2F2I
Molecular Weight	427.78 g/mol
Synonyms	1,5-Dibromo-2,4-difluoro-3-iodobenzene; 2,4-Difluoro-3-iodo-1,5-dibromobenzene; 3-Iodo-1,5-dibromo-2,4-difluorobenzene; Benzene, 1,5-dibromo-2,4-difluoro-3-iodo-; 1,5-Dibromo-2,4-difluoro-3-iodo-benzene
EINECS	Contact for details

Quality Control

Our 1,5-Dibromo-2,4-difluoro-3-iodobenzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.