Description

Azetidine, 3,3-Difluoro- (CAS NO 679431-52-8) is a highly specialized, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its unique structure, featuring a strained azetidine ring with geminal difluoro substitution, makes it a valuable precursor for introducing fluorine atoms and nitrogen-containing motifs into complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting protease inhibitors, kinase modulators, and other biologically active molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can enhance metabolic stability, bioavailability, and binding affinity.
• Fluorinated Building Block: Serves as a versatile precursor for introducing the difluoroazetidine moiety into more complex chemical architectures in organic and materials chemistry.
• Ligand and Catalyst Development: Employed in the synthesis of novel nitrogen-containing ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: Essential for academic and industrial R&D focused on exploring new chemical space, reaction methodologies, and the properties of fluorinated heterocycles.

Basic Information

Product Name	Azetidine, 3,3-Difluoro-
CAS No.	679431-52-8
Molecular Formula	C3H5F2N
Molecular Weight	93.07 g/mol
Synonyms	3,3-Difluoroazetidine; 3,3-Difluoro-azetidine; 3,3-Difluoroazacyclobutane; Azetidine, 3,3-difluoro-; 679431-52-8; 3,3-Difluoro-1-azacyclobutane; 3,3-Difluorazetidin
EINECS	Contact for details

Quality Control

Every batch of 3,3-Difluoroazetidine is produced and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by GC/HPLC), identity (by NMR, IR), and impurity profile. Our quality systems are designed to support cGMP and ISO standards for reliable and traceable material supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, keeping the material under an inert atmosphere (e.g., nitrogen or argon) in a freezer (e.g., -20°C) is recommended to maintain stability and purity. The container should be kept tightly sealed when not in use to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.