Description

3-Chloro-4-[(Morpholine-4-Carbonyl)-Amino]-Benzenesulfonyl Chloride is a high-purity, bifunctional chemical intermediate of significant importance in advanced organic synthesis. Its core value lies in providing a versatile scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality building blocks for their synthetic pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel sulfonamide-based drug candidates, including kinase inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides that utilize the sulfonyl chloride and aniline functionalities.
• Chemical Biology Probe Development: Serves as a precursor for creating activity-based probes to study enzyme function and mechanism, leveraging its reactive sulfonyl chloride group.
• Polymer & Material Science: Employed in the synthesis of specialty monomers and functional polymers, where the morpholine and sulfonyl groups impart specific material properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex, client-specific molecules.
• Research & Development: Fundamental reagent in academic and industrial R&D labs for exploring new chemical reactions and creating libraries of compounds for screening.

Basic Information

Product Name	3-Chloro-4-[(Morpholine-4-Carbonyl)-Amino]-Benzenesulfonyl Chloride
CAS No.	678185-84-7
Molecular Formula	C11H12Cl2N2O4S
Molecular Weight	339.19 g/mol
Synonyms	4-Amino-3-chlorobenzenesulfonyl chloride, N-(morpholinocarbonyl) derivative; 3-Chloro-4-[(morpholine-4-carbonyl)amino]benzenesulfonyl chloride; 4-(Morpholine-4-carbonylamino)-3-chlorobenzenesulfonyl chloride; N-(3-Chloro-4-sulfamoylphenyl)morpholine-4-carboxamide chloride; 678185-84-7; Benzenesulfonyl chloride, 3-chloro-4-[[(4-morpholinyl)carbonyl]amino]-
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-4-[(Morpholine-4-Carbonyl)-Amino]-Benzenesulfonyl Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity for demanding synthetic applications. All materials are subjected to rigorous analytical testing, including HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.