Description

4,7-Methanoisobenzofuran,1,3,3A,4,7,7A-Hexahydro-1,3-Dimethoxy-,(1R,3S,3As,4R,7S,7Ar)-Rel-(9Ci) is a high-purity, stereochemically defined bicyclic compound that serves as a critical chiral building block in advanced organic synthesis. Its unique bridged structure and defined stereochemistry make it an invaluable intermediate for constructing complex molecular architectures with high precision. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-inflammatory agents.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where its rigid, functionalized structure can impart specific biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of sophisticated chiral ligands used in asymmetric hydrogenation and C-C bond-forming reactions.
• Material Science: Investigated as a monomer or cross-linking agent for creating polymers with unique thermal and mechanical properties due to its strained bicyclic framework.
• Academic & Process Chemistry: Employed in methodological studies and scale-up process development for stereoselective synthesis routes.
• Flavor & Fragrance Intermediate: Potential use in the synthesis of complex odorants and flavor molecules that require specific stereoisomers.

Basic Information

Product Name	4,7-Methanoisobenzofuran,1,3,3A,4,7,7A-Hexahydro-1,3-Dimethoxy-,(1R,3S,3As,4R,7S,7Ar)-Rel-(9Ci)
CAS No.	678142-13-7
Molecular Formula	C11H16O3
Molecular Weight	196.24 g/mol
Synonyms	(1R,3S,3aS,4R,7S,7aR)-1,3-Dimethoxy-1,3,3a,4,7,7a-hexahydro-4,7-methanoisobenzofuran; rel-(1R,3S,3aS,4R,7S,7aR)-1,3-Dimethoxy-1,3,3a,4,7,7a-hexahydro-4,7-methano-2-benzofuran; 1,3-Dimethoxy-1,3,3a,4,7,7a-hexahydro-4,7-methanoisobenzofuran (rel-(1R,3S,3aS,4R,7S,7aR)-isomer); Hexahydro-1,3-dimethoxy-4,7-methanoisobenzofuran; Bicyclic Dimethoxy Ether Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, Chiral HPLC, and NMR to confirm identity, stereochemical purity, and impurity profile. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects with regulatory documentation as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound may be sensitive to prolonged exposure to air and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.