Description

5-Bromothiophene-2-Boronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound is a critical reagent in cross-coupling reactions, enabling the efficient construction of complex heterocyclic molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those containing functionalized thiophene cores.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific thiophene-based architectures.
• Material Science Research: Serves as a monomer or building block for creating conjugated polymers and organic electronic materials like OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugates for studying biological processes.
• Catalyst Ligand Synthesis: Useful for constructing sophisticated ligand frameworks in transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs serving the global life sciences market.

Basic Information

Product Name	5-Bromothiophene-2-Boronic Acid Pinacol Ester
CAS No.	676501-84-1
Molecular Formula	C10H14BBrO2S
Molecular Weight	289.00 g/mol
Synonyms	5-Bromo-2-thienylboronic acid pinacol ester; 2-(5-Bromothiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (5-Bromothiophen-2-yl)boronic acid pinacol ester; 5-Bromothiophene-2-boronic acid neopentyl glycol ester (common alternative); 5-Bromo-2-thienyl-B(pin); B-(5-Bromo-2-thienyl)boronic acid pinacol ester; Pinacol 5-bromothiophene-2-boronate
EINECS	Contact for details

Quality Control

Our 5-Bromothiophene-2-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥97% (by HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support cGMP compliance for advanced applications and can provide material suitable for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	< 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.