Description

(R)-(-)-1-[(S)-2-(Diphenylphosphino)-Ferrocenyl]-Ethyldi-T-Butylphosphine-(1,5-Cyclooctadiene)-Rhodium(I)]-Tetrafluoroborate is a high-value, chiral organometallic catalyst complex, specifically a rhodium(I) complex with a ferrocenyl-based Josiphos-type ligand. This compound matters for its exceptional enantioselectivity and catalytic efficiency in asymmetric hydrogenation and other transition metal-catalyzed reactions, enabling the production of single-enantiomer intermediates crucial for advanced pharmaceuticals and fine chemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of chiral active pharmaceutical ingredients (APIs) and other high-value optically pure compounds.

Application

• Asymmetric Hydrogenation Catalyst: For the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Key catalyst in the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Manufacturing: Used in the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Enables the commercial-scale synthesis of complex, optically pure fragrance and flavor compounds.
• Academic & Industrial R&D: A benchmark catalyst for developing new asymmetric synthetic methodologies and optimizing catalytic processes.
• Chiral Ligand Precursor: The complex can serve as a source of the valuable chiral phosphine ligand for other metal-catalyzed reactions.

Basic Information

Product Name	(R)-(-)-1-[(S)-2-(Diphenylphosphino)-Ferrocenyl]-Ethyldi-T-Butylphosphine-(1,5-Cyclooctadiene)-Rhodium(I)]-Tetrafluoroborate
CAS No.	673458-86-1
Molecular Formula	C40H46BF4FeP2Rh
Molecular Weight	806.33 g/mol
Synonyms	Rhodium(I)-(R)-(S)-Josiphos(COD) Tetrafluoroborate; (R)-(S)-J001-2 Rh(COD)BF4; (R)-(-)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine rhodium(I) tetrafluoroborate; Josiphos SL-J001-2 Rh(COD)BF4; Rh-((R)-(S)-J001-2)(COD)BF4; Asymmetric Hydrogenation Catalyst J001-2 Rh(COD)BF4
EINECS	Contact for details

Quality Control

Our high-purity catalyst complexes are manufactured under strict quality control protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and elemental analysis to confirm identity, purity, and enantiomeric excess of the ligand. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain long-term stability and catalytic activity. The product is light-sensitive (store away from light) and moisture-sensitive. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Rhodium Content	≥ 12.0%
Solubility	Soluble in dichloromethane, toluene, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.