Description

Senegenin is a bioactive sapogenin compound derived from the roots of *Polygala tenuifolia* (Yuan Zhi). This high-purity reference standard is critical for pharmaceutical research and quality control, serving as a key marker compound for the authentication and standardization of herbal extracts and finished products. It is primarily utilized by researchers and manufacturers in the nutraceutical, traditional medicine, and modern pharmaceutical industries developing products for cognitive and neurological health.

Application

• Pharmaceutical Reference Standard: Used as a primary chemical reference material (CRM) for the quantitative analysis and quality assurance of Polygala tenuifolia extracts and related herbal formulations.
• Nutraceutical Ingredient Standardization: Acts as a marker compound to standardize the potency and ensure batch-to-batch consistency of cognitive health and memory support dietary supplements.
• Pharmacological Research: Employed in vitro and in vivo studies to investigate mechanisms of action related to neuroprotection, anti-inflammatory effects, and cognitive enhancement.
• Herbal Medicine Quality Control: Essential for HPLC and LC-MS methods to authenticate raw herbal material, detect adulteration, and quantify senegenin content in finished products.
• Academic Research & Development: Serves as a pure compound for university and institutional research into natural product chemistry and bioactivity.

Basic Information

Product Name	Senegenin
CAS No.	667438-01-9
Molecular Formula	C30H46O7
Molecular Weight	518.69 g/mol
Synonyms	Senegenin; (3β,12β,24S)-12,24-Epoxy-3-hydroxy-24-methyl-9,11-secocholesta-5,9(11)-diene-11,23-dione; 12,24-Epoxy-3β-hydroxy-24-methyl-9,11-secocholesta-5,9(11)-diene-11,23-dione; Polygalasaponin aglycone; Tenuifolin aglycone; Yuanzhi-saponin aglycone
EINECS	Contact for details

Quality Control

Our Senegenin is produced under strict quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC for purity verification and structural confirmation via IR and MS, to ensure it meets the stringent requirements for use as a reference standard. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.