Description

4-(2,5-Dimethoxyphenyl)-5-Methyl-4H-1,2,4-Triazole-3-Thiol is a specialized heterocyclic compound featuring a triazole-thiol core substituted with a dimethoxyphenyl group. This molecular architecture makes it a valuable chemical intermediate and building block for advanced synthesis in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on novel active ingredients, particularly in the development of potential therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, due to its triazole-thiol pharmacophore.
• Agrochemical Research: Serves as a precursor for developing new fungicides, herbicides, and plant growth regulators, leveraging its heterocyclic structure for bioactivity.
• Material Science: Used in the research and development of advanced polymers, ligands for metal-organic frameworks (MOFs), and specialty chemicals requiring complex heterocyclic cores.
• Chemical Synthesis: Acts as a versatile synthon for creating libraries of 1,2,4-triazole derivatives for high-throughput screening and structure-activity relationship (SAR) studies.
• Bioconjugation & Probe Development: The thiol (-SH) group provides a handle for conjugation chemistry, useful in creating biochemical probes and labeled compounds.

Basic Information

Product Name	4-(2,5-Dimethoxyphenyl)-5-Methyl-4H-1,2,4-Triazole-3-Thiol
CAS No.	667407-74-1
Molecular Formula	C11H13N3O2S
Molecular Weight	251.31 g/mol
Synonyms	5-Methyl-4-(2,5-dimethoxyphenyl)-4H-1,2,4-triazole-3-thiol; 4-(2,5-Dimethoxyphenyl)-5-methyl-1,2,4-triazole-3-thiol; 4-(2,5-Dimethoxyphenyl)-5-methyl-4H-1,2,4-triazole-3-thione (tautomer); 667407-74-1; 5-Methyl-4-(2,5-dimethoxyphenyl)-1,2,4-triazole-3-thiol; 3H-1,2,4-Triazole-3-thione, 4-(2,5-dimethoxyphenyl)-5-methyl-; 4-(2,5-Dimethoxyphenyl)-5-methyl-1H-1,2,4-triazole-3-thiol
EINECS	Contact for details

Quality Control

Our 4-(2,5-Dimethoxyphenyl)-5-Methyl-4H-1,2,4-Triazole-3-Thiol is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its light-sensitive nature and potential for oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.