Description

4,4,5,5-Tetramethyl-2-(4-(Oxiran-2-Ylmethoxy)Phenyl)-1,3,2-Dioxaborolane is a high-value, multi-functional boronic ester derivative featuring an epoxide (oxirane) functional group. This unique bifunctional structure makes it a critical advanced intermediate for constructing complex molecules in pharmaceutical and materials science research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and polymer industries for applications requiring precise molecular coupling and controlled polymerization.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronate ester reagent for forming carbon-carbon bonds in the synthesis of complex biaryl structures for active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, particularly where the epoxide moiety allows for further functionalization or acts as a pharmacophore.
• Polymer & Material Science: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers, epoxy resins, and advanced materials, leveraging the reactivity of both the boronic ester and epoxide groups.
• Agrochemical Synthesis: Employed as a building block in the creation of new herbicides, fungicides, and insecticides with tailored properties.
• Liquid Crystal & OLED Materials: Utilized in the development of organic electronic materials due to its ability to introduce rigid, conjugated structures.
• Protecting Group Strategy: The boronic ester group can act as a protecting group for diols or as a handle for further synthetic transformations in multi-step organic synthesis.

Basic Information

Item	Details
Product Name	4,4,5,5-Tetramethyl-2-(4-(Oxiran-2-Ylmethoxy)Phenyl)-1,3,2-Dioxaborolane
CAS No.	664991-83-7
Molecular Formula	C₁₇H₂₅BO₄
Molecular Weight	304.19 g/mol
Synonyms	2-(4-(Oxiran-2-ylmethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-[4-(oxiran-2-ylmethoxy)phenyl]-1,3,2-dioxaborolane; 2-(4-(Glycidyloxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-(Glycidyloxy)phenyl)boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl glycidyl ether; Epoxy phenyl pinacol boronate; Glycidyloxyphenyl pinacol boronic ester
EINECS	Contact for details

Quality Control

Our production of 4,4,5,5-Tetramethyl-2-(4-(Oxiran-2-Ylmethoxy)Phenyl)-1,3,2-Dioxaborolane adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as assay (HPLC), identity (IR, NMR), and impurity profiles. We support our clients' regulatory needs with comprehensive documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Related Substances (HPLC)	Total impurities ≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.