Description

3-(3,5-Bis-Trifluoromethyl-Phenyl)-Propionitrile is a high-value fluorinated aromatic nitrile building block, essential for synthesizing advanced pharmaceutical intermediates and agrochemicals. Its unique trifluoromethylated aromatic core imparts desirable properties such as enhanced metabolic stability and lipophilicity to target molecules. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the trifluoromethyl groups improve biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of fluorinated polymers and liquid crystals for electronic and optical applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3-(3,5-Bis-Trifluoromethyl-Phenyl)-Propionitrile
CAS No.	663884-63-7
Molecular Formula	C11H5F6N
Molecular Weight	265.16 g/mol
Synonyms	3-[3,5-Bis(trifluoromethyl)phenyl]propanenitrile; 3,5-Bis(trifluoromethyl)phenylpropionitrile; 3-(3,5-Bis(trifluoromethyl)phenyl)propionitrile; 3,5-Bis(trifluoromethyl)benzenepropanenitrile; α,α,α,α',α',α'-Hexafluoro-3,5-xylylethyl cyanide; 3-(3,5-Di(trifluoromethyl)phenyl)propionitrile
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity for this advanced intermediate. Our standard quality control includes comprehensive analysis via HPLC, GC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We can support development projects with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Keep away from heat, sparks, open flames, and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.