Description

(E)-3-(4-Amino-3,5-Dimethylphenyl)Acrylonitrile Hydrochloride is a high-purity, functionalized acrylonitrile derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring an amino group and an acrylonitrile moiety, makes it a versatile intermediate for constructing complex molecules with specific electronic and steric properties. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of tyrosine kinase inhibitors and other targeted small-molecule therapeutics.
• Agrochemical Research: Building block for developing new herbicides and plant growth regulators that require specific aromatic amine functionality.
• Material Science: Monomer or cross-linking agent in the production of specialty polymers, including photosensitive resins and advanced composites.
• Organic Synthesis: Versatile reagent for Michael addition reactions and cyclization processes to create heterocyclic compounds.
• Dye & Pigment Intermediate: Used in the synthesis of advanced colorants and optical brightening agents.
• Bioconjugation Chemistry: The reactive acrylonitrile group can be utilized for labeling biomolecules in diagnostic assay development.

Basic Information

Product Name	(E)-3-(4-Amino-3,5-Dimethylphenyl)Acrylonitrile Hydrochloride
CAS No.	661489-23-2
Molecular Formula	C11H11N2·HCl
Molecular Weight	206.68 (Free base) / 243.13 (Hydrochloride salt)
Synonyms	(E)-3-(4-Amino-3,5-dimethylphenyl)-2-propenenitrile hydrochloride; (E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile HCl; (E)-3-(4-Amino-3,5-dimethylphenyl)prop-2-enenitrile hydrochloride; trans-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile hydrochloride; 4-Amino-3,5-dimethylcinnamonitrile hydrochloride; CAS 661489-23-2; 2-Propenenitrile, 3-(4-amino-3,5-dimethylphenyl)-, hydrochloride, (E)-
EINECS	Contact for details

Quality Control

Our (E)-3-(4-Amino-3,5-Dimethylphenyl)Acrylonitrile Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.