Description

1-(2-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenoxy]-Ethyl)-Pyrrolidine is a high-value, synthetically versatile boronic ester derivative that serves as a critical building block in modern organic synthesis. Its primary value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity intermediates for their R&D and production workflows.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides by facilitating the formation of biaryl and heterobiaryl structures.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers for OLEDs and OFETs, where precise molecular architecture is required.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules and probes for studying biological pathways and protein interactions.
• Scale-up Process Development: Serves as a reliable intermediate for process chemistry teams optimizing routes from laboratory to pilot and commercial scale.

Basic Information

Product Name	1-(2-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenoxy]-Ethyl)-Pyrrolidine
CAS No.	656257-46-4
Molecular Formula	C18H28BNO3
Molecular Weight	317.24 g/mol
Synonyms	2-[4-[2-(Pyrrolidin-1-yl)ethoxy]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-[2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]pyrrolidine; 4-(2-Pyrrolidin-1-ylethoxy)benzeneboronic acid pinacol ester; Pyrrolidine, 1-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]-; 656257-46-4; Boronic acid, B-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 1-(2-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenoxy]-Ethyl)-Pyrrolidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as assay (HPLC/NMR), identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.