Description

3-(4-Fluorophenyl)-4'-Trifluoromethylpropiophenone is a high-purity fluorinated aromatic ketone intermediate of significant importance in advanced organic synthesis. Its value lies in its unique molecular structure, which incorporates both fluorophenyl and trifluoromethyl groups, making it a versatile building block for creating complex molecules with tailored properties. This compound is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or building block for developing specialty polymers, liquid crystals, and organic electronic materials with specific optical or electrical properties.
• Chemical Biology & Probe Development: Utilized in the creation of fluorinated molecular probes and tags for imaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-(4-Fluorophenyl)-4'-Trifluoromethylpropiophenone
CAS No.	654673-19-5
Molecular Formula	C₁₆H₁₂F₄O
Molecular Weight	296.26 g/mol
Synonyms	1-[4-(Trifluoromethyl)phenyl]-3-(4-fluorophenyl)propan-1-one; 4'-Trifluoromethyl-3-(4-fluorophenyl)propiophenone; 3-(p-Fluorophenyl)-1-[4-(trifluoromethyl)phenyl]propan-1-one; 3-(4-Fluorophenyl)-1-[4-(trifluoromethyl)phenyl]-1-propanone; Propiophenone, 3-(4-fluorophenyl)-4'-(trifluoromethyl)-; 654673-19-5
EINECS	Contact for details

Quality Control

Our 3-(4-Fluorophenyl)-4'-Trifluoromethylpropiophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.