Description

6-Bromo-2,4-Difluoro-3-(Trimethylsilyl)Benzaldehyde is a high-value, multi-functional aromatic aldehyde building block featuring bromo, fluoro, and trimethylsilyl substituents. This compound is strategically important for its role in facilitating complex cross-coupling reactions and serving as a versatile precursor in advanced organic synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries to construct novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for sophisticated ligands used in transition metal catalysis, such as palladium-catalyzed cross-couplings (Suzuki, Buchwald-Hartwig).
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other functional materials where the silyl and halogen groups modulate electronic properties.
• Custom Synthesis & Scale-Up: An essential building block for contract research organizations (CROs) and custom synthesis providers working on proprietary compounds for clients.

Basic Information

Product Name	6-Bromo-2,4-Difluoro-3-(Trimethylsilyl)Benzaldehyde
CAS No.	651326-71-5
Molecular Formula	C10H11BrF2OSi
Molecular Weight	293.18 g/mol
Synonyms	3-Bromo-5,6-Difluoro-2-(trimethylsilyl)benzaldehyde; 2,4-Difluoro-6-bromo-3-(trimethylsilyl)benzaldehyde; Benzaldehyde, 6-bromo-2,4-difluoro-3-(trimethylsilyl)-; 651326-71-5; 6-Bromo-2,4-difluoro-3-trimethylsilylbenzaldehyde
EINECS	Contact for details

Quality Control

Every batch of 6-Bromo-2,4-Difluoro-3-(Trimethylsilyl)Benzaldehyde is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity (typically ≥95% by HPLC), and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. Keep the container in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.