Description

2H-1,3-Benzoxazine-3(4H)-Propanol,4-Ethyl-,(-)-(9Ci) is a chiral, optically active benzoxazine derivative, a class of compounds known for their versatile chemical reactivity and biological significance. This specific enantiomer is a valuable chiral building block and intermediate for the synthesis of complex molecules in advanced research and development. It is primarily utilized by pharmaceutical, agrochemical, and specialty chemical manufacturers engaged in the development of novel active ingredients. The compound, identified by CAS NO 651305-09-8, offers a defined stereochemical handle for creating enantiomerically pure products with targeted properties.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) agents or other biologically active molecules.
• Agrochemical Synthesis: Used as a building block for creating novel, enantiomerically pure pesticides, herbicides, or plant growth regulators with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands for asymmetric catalysis or as a precursor for functional materials in chemical synthesis.
• Advanced Material Research: Acts as a monomer or precursor in the development of specialized polymers, resins, or coatings with unique thermal or mechanical properties derived from the benzoxazine ring.
• Organic Synthesis & Medicinal Chemistry: Provides a versatile scaffold for constructing complex heterocyclic compounds in academic and industrial research laboratories.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	2H-1,3-Benzoxazine-3(4H)-Propanol,4-Ethyl-,(-)-(9Ci)
CAS No.	651305-09-8
Molecular Formula	C₁₃H₁₇NO₂
Molecular Weight	219.28 g/mol
Synonyms	(-)-4-Ethyl-3-(3-hydroxypropyl)-3,4-dihydro-2H-1,3-benzoxazine; (3S)-4-Ethyl-3-(3-hydroxypropyl)-3,4-dihydro-2H-1,3-benzoxazine; 4-Ethyl-3-(3-hydroxypropyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine; 651305-09-8; Benzoxazine derivative C13H17NO2; (-)-enantiomer of 4-Ethyl-3-(3-hydroxypropyl)-2H-1,3-benzoxazine
EINECS	Contact for details

Quality Control

Our 2H-1,3-Benzoxazine-3(4H)-Propanol,4-Ethyl-,(-)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. A detailed Certificate of Analysis (COA) providing specifications for identity, assay, chiral purity, and related substances is supplied with every shipment. We support cGMP compliance for advanced intermediates and can provide regulatory support documentation as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.