Description

1-Bromo-3,5-Difluoro-4-(Methylsulfanyl)Benzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a methylthioether group, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates where the difluoro and bromo substituents are crucial for metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for creating specialized aromatic cores in electronic materials, contributing to the performance of displays and lighting.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Heck, Stille), enabling efficient carbon-carbon bond formation for complex molecule assembly.
• Functional Material Research: Employed in the synthesis of ligands for catalysis, organic semiconductors, and other advanced polymers requiring specific halogen and sulfur functionalities.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	1-Bromo-3,5-Difluoro-4-(Methylsulfanyl)Benzene
CAS No.	648905-87-7
Molecular Formula	C7H5BrF2S
Molecular Weight	239.08 g/mol
Synonyms	4-Bromo-2,6-Difluoro(methylthio)benzene; 3,5-Difluoro-4-(Methylthio)Bromobenzene; 1-Bromo-3,5-difluoro-4-methylsulfanylbenzene; 4-Bromo-2,6-difluoro-1-(methylsulfanyl)benzene; Benzene, 1-bromo-3,5-difluoro-4-(methylthio)-; (2,6-Difluoro-4-bromophenyl)(methyl)sulfane
EINECS	Contact for details

Quality Control

Our 1-Bromo-3,5-Difluoro-4-(Methylsulfanyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent lot-to-lot performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated industry segments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.