Description

4,4,5,5-Tetramethyl-2-(4-((Trifluoromethyl)Sulfonyl)Phenyl)-1,3,2-Dioxaborolane is a high-purity, advanced pharmaceutical intermediate and key building block in modern synthetic chemistry. This compound is valued for its role as a versatile boronic ester, enabling critical carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional molecules. The product, identified by CAS NO 648904-89-6, is supplied to meet the stringent demands of process development and scale-up.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing aryl and heteroaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, reactive boronic ester partner for palladium-catalyzed coupling to construct biaryl and complex conjugated systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific aryl-boronate functionalities.
• Materials Science & OLED Development: A building block for creating organic light-emitting diode (OLED) materials, conductive polymers, and other advanced organic electronic components.
• Chemical Research & Process Development: Enables medicinal chemistry and route scouting for novel compound libraries in academic and industrial R&D settings.
• Ligand and Catalyst Preparation: Utilized in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis.

Basic Information

Item	Details
Product Name	4,4,5,5-Tetramethyl-2-(4-((Trifluoromethyl)Sulfonyl)Phenyl)-1,3,2-Dioxaborolane
CAS No.	648904-89-6
Molecular Formula	C13H16BF3O4S
Molecular Weight	336.14 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-[4-(trifluoromethylsulfonyl)phenyl]-1,3,2-dioxaborolane; 2-(4-(Trifluoromethylsulfonyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl trifluoromethyl sulfone; 4-(Trifluoromethylsulfonyl)phenylboronic acid pinacol ester; 4-(Trifluoromethanesulfonyl)phenylboronic acid pinacol ester; 4-Pinacolatoboronylphenyl trifluoromethyl sulfone
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(4-((Trifluoromethyl)Sulfonyl)Phenyl)-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.