Description

Cyclohexanecarboxylic Acid, 4-Fluoro-3-Hydroxy-, (1R,3R,4R)-Rel- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, featuring a fluorinated, hydroxylated cyclohexane ring system with defined stereochemistry, which is crucial for imparting specific biological activity and metabolic stability to target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly where precise three-dimensional structure is a critical design parameter.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in areas targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infectives.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the fluorine atom and specific stereochemistry enhance bioactivity and environmental persistence profiles.
• Advanced Material Precursor: Serves as a building block for specialty polymers, liquid crystals, or organic electronic materials requiring fluorinated cycloaliphatic components.
• Asymmetric Catalysis Ligand Scaffold: The hydroxyl and carboxylic acid functionalities provide handles for modification into novel chiral ligands or organocatalysts.
• Chemical Biology Probe Development: Utilized in medicinal chemistry to study structure-activity relationships (SAR) and for the synthesis of labeled compounds for metabolic studies.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Cyclohexanecarboxylic Acid, 4-Fluoro-3-Hydroxy-, (1R,3R,4R)-Rel- (9Ci)
CAS No.	648419-95-8
Molecular Formula	C7H11FO3
Molecular Weight	162.16 g/mol
Synonyms	(1R,3R,4R)-4-Fluoro-3-hydroxycyclohexanecarboxylic acid; rel-(1R,3R,4R)-4-Fluoro-3-hydroxycyclohexane-1-carboxylic acid; 4-Fluoro-3-hydroxycyclohexanecarboxylic acid (rel-(1R,3R,4R)-); Fluorohydroxycyclohexanecarboxylic acid; (1R,3R,4R)-4-Fluoro-3-hydroxy-1-cyclohexanecarboxylic acid; Cyclohexanecarboxylic acid, 4-fluoro-3-hydroxy-, (1R,3R,4R)-rel-
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity essential for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including Chiral HPLC, 1H/19F/13C NMR, and mass spectrometry to confirm identity, stereochemical purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (rel-(1R,3R,4R)-)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.