Description

1-Bromo-2-(Bromomethyl)-4,5-Difluorobenzene, also known as Alpha,2-Dibromo-4,5-Difluorotoluene, is a high-value, multi-functional halogenated aromatic building block. Its unique structure, featuring both bromine and fluorine substituents, makes it a critical intermediate for introducing specific reactivity and lipophilicity into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require precise, high-purity intermediates for advanced synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated and brominated aromatic cores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the difluorobenzene moiety contributes to efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the research and production of organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: The bromine atoms provide excellent handles for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct complex molecular architectures.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and creating novel fluorinated compounds in academic and industrial R&D labs.

Basic Information

Product Name	1-Bromo-2-(Bromomethyl)-4,5-Difluorobenzene
CAS No.	647862-95-1
Molecular Formula	C7H4Br2F2
Molecular Weight	285.91 g/mol
Synonyms	Alpha,2-Dibromo-4,5-Difluorotoluene; 2-(Bromomethyl)-1-bromo-4,5-difluorobenzene; 1-Bromo-2-(bromomethyl)-4,5-difluorobenzene; 4,5-Difluoro-2-(bromomethyl)bromobenzene; (2-Bromomethyl)-1-bromo-4,5-difluorobenzene; 2-Bromomethyl-1-bromo-4,5-difluorobenzene; Benzene, 1-bromo-2-(bromomethyl)-4,5-difluoro-
EINECS	Contact for details

Quality Control

Our production of 1-Bromo-2-(Bromomethyl)-4,5-Difluorobenzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all critical specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 2°C and 8°C for long-term stability, although the product is typically stable at controlled room temperature for shorter periods. Handle and store under an inert atmosphere if prolonged storage is required.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.