Description

6-Chlorospiro[Chroman-2,4'-Piperidine] is a sophisticated spirocyclic organic compound featuring a chroman ring fused to a piperidine moiety via a spiro carbon center. This unique molecular architecture makes it a valuable and versatile pharmaceutical intermediate and building block for medicinal chemistry research. It is primarily utilized in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders and other therapeutic areas. Industries engaged in advanced organic synthesis, including pharmaceutical R&D and fine chemical manufacturing, require this high-purity compound for developing next-generation active pharmaceutical ingredients (APIs).

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a critical precursor in the development of novel drug candidates, particularly for CNS-targeting therapies.
• Medicinal Chemistry Building Block: Used in structure-activity relationship (SAR) studies and combinatorial chemistry libraries to explore new bioactive molecules.
• Research and Development (R&D): Essential for academic and industrial research focused on neuropharmacology and heterocyclic chemistry.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals.
• Ligand and Probe Development: Potential use in creating chemical probes for studying biological receptors and enzymes.

Basic Information

Product Name	6-Chlorospiro[Chroman-2,4'-Piperidine]
CAS No.	644968-50-3
Molecular Formula	C13H16ClNO
Molecular Weight	237.73 g/mol
Synonyms	6-Chloro-1'-azaspiro[chroman-2,4'-piperidine]; 6-Chloro-1-azaspiro[4.5]decan-8-one; 6-Chlorospiro(chroman-2,4'-piperidine); 6-Chloro-2,3-dihydrospiro[1-benzopyran-2,4'-piperidine]; 6-Chloro-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]; 6-Chloro-3,4-dihydrospiro[chromene-2,4'-piperidine]; 6-Chloro-1-azaspiro[4.5]decan-8-one (related structure); Spiro[chroman-2,4'-piperidine], 6-chloro-
EINECS	Contact for details

Quality Control

Our 6-Chlorospiro[Chroman-2,4'-Piperidine] is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and synthesis. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry for comprehensive characterization. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.