Description

4-(Triisopropylsilyloxy)Phenyl Boronic Acid is a high-value organoboron building block featuring a sterically hindered triisopropylsilyl (TIPS) protecting group. This compound is critical for modern synthetic chemistry, enabling precise cross-coupling reactions essential for constructing complex molecular architectures. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of new active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl compounds, a common scaffold in pharmaceuticals and organic electronics.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for constructing sterically hindered, complex aromatic systems.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced properties.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its defined geometry and reactivity.
• Process Chemistry & Scale-Up: Provides a reliable and pure starting material for optimizing and scaling synthetic routes from lab to pilot plant.
• Protecting Group Strategy: The TIPS group offers robust protection for phenolic hydroxyls during multi-step syntheses, which can be selectively removed under mild conditions.

Basic Information

Product Name	4-(Triisopropylsilyloxy)Phenyl Boronic Acid
CAS No.	643090-93-1
Molecular Formula	C15H27BO3Si
Molecular Weight	294.27 g/mol
Synonyms	[4-(Triisopropylsilyloxy)phenyl]boronic acid; 4-(Triisopropylsiloxy)benzeneboronic acid; p-(Triisopropylsilyloxy)phenylboronic acid; B-[4-[(Triisopropylsilyl)oxy]phenyl]boronic acid; 4-TIPS-O-PhB(OH)2; TIPS-Protected 4-Hydroxyphenylboronic Acid; 4-Hydroxyphenylboronic Acid TIPS Ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and process chemistry. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, NMR, and HPLC are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.