Description

Indole-6-Boronic Acid Pinacol Ester is a high-value organoboron building block, specifically a protected boronic acid derivative. This compound is critical for enabling efficient and selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental to modern synthetic chemistry. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex heterocyclic molecules. The pinacol ester group enhances stability and handling compared to the free boronic acid, ensuring reliable performance in sensitive synthetic sequences.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly those containing the indole scaffold, which is prevalent in bioactive molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides through structure-activity relationship (SAR) studies.
• Material Science: Serves as a precursor for creating organic electronic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Chemical Biology & Probe Development: Employed in the synthesis of fluorescent tags, molecular probes, and bioconjugates for diagnostic and research applications.
• Catalyst & Ligand Synthesis: Used to construct sophisticated ligands for transition metal catalysis.
• Academic & Contract Research: Essential for methodological development and exploratory synthesis in university and CRO laboratories worldwide.

Basic Information

Product Name	Indole-6-Boronic Acid Pinacol Ester
CAS No.	642494-36-8
Molecular Formula	C₁₄H₁₈BNO₂
Molecular Weight	243.11 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 1H-Indole-6-boronic acid pinacol ester; 6-Indolylboronic acid pinacol ester; 6-(Pinacolatoboryl)-1H-indole; Indol-6-ylboronic acid pinacol ester; B-(1H-Indol-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 6-Boronindole pinacol ester
EINECS	Contact for details

Quality Control

Every batch of Indole-6-Boronic Acid Pinacol Ester is manufactured and tested under strict quality management systems. We ensure high purity and batch-to-batch consistency through advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. Our quality commitment aligns with the standards required for cGMP and ISO-guided applications in research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (argon or nitrogen) for long-term storage to maintain optimal purity and reactivity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.