Description

tert-Butyl 8-Formyl-3-Azabicyclo[3.2.1]Octane-3-Carboxylate CAS NO 637301-17-8 is a high-value, protected bicyclic amino acid derivative featuring a reactive aldehyde functional group. This compound serves as a critical advanced pharmaceutical intermediate (API) for constructing complex molecular architectures in drug discovery and development. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutics, particularly in the areas of central nervous system (CNS) agents and complex alkaloid analogs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those with complex polycyclic or bridged ring systems.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its versatile aldehyde handle for further derivatization (e.g., reductive amination, condensation).
• Peptidomimetic Synthesis: Serves as a constrained, non-proteinogenic amino acid analog for creating conformationally restricted peptides with enhanced metabolic stability.
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for studying biological targets and pathways.
• Asymmetric Synthesis: Acts as a chiral scaffold or starting material for the preparation of enantiomerically pure compounds in asymmetric catalysis.
• Academic & Industrial R&D: Fundamental research reagent for exploring new synthetic methodologies and reaction pathways involving bicyclic amines.

Basic Information

Item	Details
Product Name	tert-Butyl 8-Formyl-3-Azabicyclo[3.2.1]Octane-3-Carboxylate
CAS No.	637301-17-8
Molecular Formula	C13H21NO3
Molecular Weight	239.31 g/mol
Synonyms	8-Formyl-3-azabicyclo[3.2.1]octane-3-carboxylic acid tert-butyl ester; 3-[(1,1-Dimethylethoxy)carbonyl]-3-azabicyclo[3.2.1]octane-8-carboxaldehyde; 3-Boc-3-azabicyclo[3.2.1]octane-8-carbaldehyde; 3-Azabicyclo[3.2.1]octane-8-carboxaldehyde, 3-[(1,1-dimethylethoxy)carbonyl]-; tert-Butyl 8-formyl-3-azabicyclo[3.2.1]octane-3-carboxylate; 3-Boc-8-formyl-3-azabicyclo[3.2.1]octane; Bicyclic amino aldehyde derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Formyl-3-Azabicyclo[3.2.1]Octane-3-Carboxylate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or GMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is easily oxidized (store under inert atmosphere) and light-sensitive. Keep container tightly sealed under an inert gas blanket (e.g., nitrogen or argon) to maximize shelf life and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.