Description

3,3-Difluorocyclobutanol is a versatile fluorinated cyclobutane derivative of significant interest in advanced organic synthesis. Its unique structure, featuring a cyclobutanol ring with geminal fluorine atoms, makes it a valuable building block for creating complex molecules with tailored properties. This compound is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, leveraging fluorine's ability to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the difluorocyclobutyl moiety can enhance biological activity and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts in asymmetric synthesis, exploiting the steric and electronic properties of the cyclobutane ring.
• Material Science Precursor: Potential building block for fluorinated polymers or liquid crystals, contributing to thermal stability and unique optical properties.
• Fluorine Chemistry Research: An important substrate for studying ring strain effects and novel fluorination reactions in strained carbocyclic systems.

Basic Information

Product Name	3,3-Difluorocyclobutanol
CAS No.	637031-88-0
Molecular Formula	C4H6F2O
Molecular Weight	108.09 g/mol
Synonyms	3,3-Difluorocyclobutan-1-ol; 1-Hydroxy-3,3-difluorocyclobutane; Difluorocyclobutanol; 3,3-Difluorocyclobutyl alcohol; 637031-88-0; 3,3-Difluoro-1-hydroxycyclobutane; Cyclobutanol, 3,3-difluoro-
EINECS	Contact for details

Quality Control

Our 3,3-Difluorocyclobutanol is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your R&D and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.