Description

((3,3-Difluorocyclobutoxy)Methyl)Benzene is a high-purity fluorinated organic building block of significant interest in advanced chemical synthesis. This compound matters for its unique structural motif, which incorporates a difluorocyclobutyl ether moiety attached to a benzyl group, offering valuable steric and electronic properties for molecular design. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors or GPCR modulators.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluorocyclobutyl group can enhance metabolic stability and bioavailability.
• Liquid Crystal & OLED Materials: Serves as a precursor or core structure in the synthesis of fluorinated components for electronic display materials.
• Polymer Science: Acts as a monomer or modifier for introducing fluorinated segments into specialty polymers to alter surface properties and chemical resistance.
• Cross-Coupling Reactions: The benzyl moiety can be functionalized, making it a versatile substrate for Suzuki, Heck, or other palladium-catalyzed coupling reactions.
• Chemical Research: Employed in academic and industrial labs to explore new fluorination methodologies and the properties of strained ring systems.

Basic Information

Product Name	((3,3-Difluorocyclobutoxy)Methyl)Benzene
CAS No.	637031-86-8
Molecular Formula	C11H12F2O
Molecular Weight	198.21 g/mol
Synonyms	Benzyl 3,3-difluorocyclobutyl ether; (3,3-Difluorocyclobutyloxymethyl)benzene; α-((3,3-Difluorocyclobutoxy)methyl)benzene; 1-(((3,3-Difluorocyclobutyl)oxy)methyl)benzene; (Benzyloxymethyl)-3,3-difluorocyclobutane; 637031-86-8; (3,3-Difluorocyclobutoxy)methylbenzene
EINECS	Contact for details

Quality Control

Our ((3,3-Difluorocyclobutoxy)Methyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.