Description

Methyl 3,5-Di-o-(2,4-Dichlorobenzyl)-D-Ribofuranoside is a key protected ribofuranoside derivative, a crucial chiral building block in advanced organic synthesis. Its value lies in providing a chemically defined, enantiomerically pure scaffold for constructing complex nucleoside analogs and other bioactive molecules. This high-purity intermediate is essential for research and development in the pharmaceutical industry, particularly for antiviral and anticancer drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of novel nucleoside-based therapeutics.
• Antiviral Drug Research: Used in the development of prodrugs and modified nucleosides targeting viral polymerases.
• Anticancer Agent Development: Acts as a building block for creating nucleoside analogs that interfere with cancer cell DNA/RNA synthesis.
• Medicinal Chemistry: Provides a protected sugar moiety for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Bioconjugation & Probe Synthesis: Useful for creating labeled nucleosides for diagnostic or biochemical research applications.

Basic Information

Product Name	Methyl 3,5-Di-o-(2,4-Dichlorobenzyl)-D-Ribofuranoside
CAS No.	636581-81-2
Molecular Formula	C21H22Cl4O5
Molecular Weight	504.21 g/mol
Synonyms	Methyl 3,5-Di-O-(2,4-dichlorobenzyl)-D-ribofuranoside; D-Ribofuranoside, methyl 3,5-bis-O-(2,4-dichlorobenzyl)-; Methyl 3,5-bis-O-(2,4-dichlorobenzyl)-D-ribofuranoside; 3,5-Di-O-(2,4-dichlorobenzyl)-methyl-D-ribofuranoside; Protected Methyl Ribofuranoside; 2,4-Dichlorobenzyl Protected Riboside
EINECS	Contact for details

Quality Control

Our Methyl 3,5-Di-o-(2,4-Dichlorobenzyl)-D-Ribofuranoside is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.