Description

Dichloro[1,3-Bis(2,6-Isopropylphenyl)-2-Imidazolidinylidene](2-Isopropoxyphenylmethylene)Ruthenium(II) is a highly specialized, second-generation Grubbs-Hoveyda type olefin metathesis catalyst. This compound matters for its exceptional thermal stability and functional group tolerance, enabling precise and efficient carbon-carbon double bond formation in complex molecular architectures. It is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing active ingredients, fine chemicals, and specialty polymers.

Application

• Pharmaceutical Intermediate Synthesis: Key catalyst for ring-closing metathesis (RCM), cross-metathesis (CM), and ring-opening metathesis polymerization (ROMP) in the production of complex drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring the construction of specific olefinic frameworks.
• Advanced Material Fabrication: Enables the synthesis of specialty polymers, functionalized surfaces, and self-healing materials via controlled ROMP reactions.
• Fine Chemical and Fragrance Manufacturing: Facilitates the efficient and selective construction of olefin bonds in high-value, low-volume specialty chemicals.
• Academic and Industrial R&D: A staple catalyst in research laboratories for methodology development and the synthesis of novel organic compounds.
• Process Chemistry Optimization: Valued for its robustness in scaling up metathesis reactions from laboratory to pilot plant scale.

Basic Information

Item	Details
Product Name	Dichloro[1,3-Bis(2,6-Isopropylphenyl)-2-Imidazolidinylidene](2-Isopropoxyphenylmethylene)Ruthenium(II)
CAS No.	635679-24-2
Molecular Formula	C34H44Cl2N2ORu
Molecular Weight	664.70 g/mol
Synonyms	Grubbs-Hoveyda Catalyst 2nd Generation; Hoveyda-Grubbs Catalyst II; (1,3-Bis(2,6-Diisopropylphenyl)-2-imidazolidinylidene)dichloro(2-isopropoxyphenylmethylene)ruthenium; HG II; Zhan Catalyst 1B; Dichloro(o-isopropoxyphenylmethylene)(1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene)ruthenium(II); Dichloro(1,3-bis(2,6-diisopropylphenyl)-2-imidazolidinylidene)(2-isopropoxyphenylmethylene)ruthenium; RuCl2(=CH(2-iPrO-C6H4))(H2IMes)
EINECS	Contact for details

Quality Control

Every batch of our Grubbs-Hoveyda II catalyst is manufactured and tested under stringent quality protocols to ensure high catalytic activity and batch-to-batch consistency. Our quality system is designed to meet the exacting standards of process chemistry and advanced R&D. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing key parameters such as purity, identity, and catalytic performance indicators.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. This material is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers must be sealed immediately after use and kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Green to brownish-green crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Solubility	Soluble in common organic solvents (DCM, toluene, THF)
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.