Description

(1S,2S,5R,6R)-Di-tert-Butyl 2-(tert-Butoxycarbonyl)-4-Oxobicyclo[3.1.0]Hexane-2,6-Dicarboxylate is a highly functionalized bicyclic compound that serves as a critical chiral building block and advanced synthetic intermediate. Its value lies in its rigid, strained bicyclo[3.1.0]hexane scaffold and multiple protected carboxylate groups, enabling precise stereochemical control in complex molecule assembly. This product is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and exploring new chemical space.

Application

• Pharmaceutical Intermediate: Key chiral precursor for the synthesis of complex drug candidates, including potential antiviral, anticancer, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Building block for creating novel pesticides and herbicides with specific stereochemistry for enhanced biological activity and selectivity.
• Material Science Research: Used in the development of specialty polymers and advanced materials where the strained ring system imparts unique physical properties.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing sophisticated chiral ligands and organocatalysts.
• Academic & Process Chemistry: A valuable tool for methodological development in organic synthesis, including cyclopropanation and ring-expansion studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	(1S,2S,5R,6R)-Di-tert-Butyl 2-(tert-Butoxycarbonyl)-4-Oxobicyclo[3.1.0]Hexane-2,6-Dicarboxylate
CAS No.	635318-04-6
Molecular Formula	C21H32O7
Molecular Weight	396.48 g/mol
Synonyms	(1S,2S,5R,6R)-Di-tert-butyl 2-[(tert-butoxy)carbonyl]-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylate; 4-Oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester, (1S,2S,5R,6R)-; Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative; tert-Butyl (1S,2S,5R,6R)-2,6-bis(tert-butoxycarbonyl)-4-oxobicyclo[3.1.0]hexane-2-carboxylate; Chiral bicyclo[3.1.0]hexane intermediate; CAS 635318-04-6
EINECS	Contact for details

Quality Control

Our (1S,2S,5R,6R)-Di-tert-Butyl 2-(tert-Butoxycarbonyl)-4-Oxobicyclo[3.1.0]Hexane-2,6-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development from research to commercial scale with consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.