Description

3-Chloro-4-Fluorophenylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key reagent in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides requiring specific halogenated biphenyl structures.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs and organic photovoltaics, where fluorinated and chlorinated motifs are valuable.
• Chemical Biology Probes: Utilized to build molecular probes and tags for studying biological processes and protein interactions.
• Scale-up & Process Chemistry: The pinacol ester protection offers enhanced stability and handling properties, making it suitable for multi-step synthesis and pilot-scale production.

Basic Information

Product Name	3-Chloro-4-Fluorophenylboronic Acid Pinacol Ester
CAS No.	635305-46-3
Molecular Formula	C12H15BClFO2
Molecular Weight	255.51 g/mol
Synonyms	(3-Chloro-4-fluorophenyl)boronic acid pinacol ester; 2-(3-Chloro-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-4-fluorobenzeneboronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(3-chloro-4-fluorophenyl)-1,3,2-dioxaborolane; Pinacol (3-Chloro-4-fluorophenyl)boronate; 3-Chloro-4-fluoro phenylboronic acid pinacol ester; Boronic acid, B-(3-chloro-4-fluorophenyl)-, 1,1-dimethylethyl ester (9CI)
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full traceability are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be stored away from light. Keep the container tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.