Description

4,4,5,5-Tetramethyl-2-(2-thienylethynyl)-1,3,2-dioxaborolane is a high-value organoboron building block, specifically a thiophene-substituted pinacol boronic ester, essential for modern cross-coupling chemistry. Its core value lies in enabling the precise and efficient synthesis of complex heterocyclic molecules, which are critical scaffolds in advanced material and pharmaceutical research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for constructing novel thiophene-based derivatives.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for introducing the 2-ethynylthiophene moiety into complex molecular architectures, enabling carbon-carbon bond formation under mild conditions.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs) that incorporate thiophene heterocycles, which are prevalent in drugs targeting various therapeutic areas.
• Agrochemical Product Development: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Organic Semiconductor and OLED Material Research: Fundamental for synthesizing conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), field-effect transistors (OFETs), and photovoltaic cells.
• Ligand and Catalyst Design: Employed in the preparation of specialized ligands for transition metal catalysis, facilitating novel reaction pathways.
• Polymer and Advanced Material Science: Acts as a monomer or functionalization agent for creating polymers with tailored electronic or optical properties.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(2-thienylethynyl)-1,3,2-dioxaborolane
CAS No.	634196-64-8
Molecular Formula	C14H19BO2S
Molecular Weight	262.17 g/mol
Synonyms	2-(2-Thienylethynyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(Thiophen-2-ylethynyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (Thiophen-2-ylethynyl)pinacolborane; 2-Ethynylthiophene pinacol boronic ester; 2-Thienylacetylene pinacol boronate; Pinacol (2-thienylethynyl)boronate; CAS 634196-64-8
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(2-thienylethynyl)-1,3,2-dioxaborolane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, critical for sensitive cross-coupling applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of research and development in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.