Description

(E)-2-(2-Fluorostyryl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 633327-38-5 is a high-purity, advanced pharmaceutical intermediate belonging to the class of vinyl boronic esters. This compound is a critical building block in modern synthetic organic chemistry, enabling efficient cross-coupling reactions to construct complex molecular architectures. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for the development of novel active ingredients and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex organic molecules, particularly for introducing fluorinated styrenyl motifs.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and production of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of new generation herbicides, fungicides, and insecticides that require specific fluorinated structures for enhanced activity and selectivity.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and advanced polymers where the fluorostyryl-boronate unit imparts desired electronic or optical properties.
• Chemical Biology & Probe Development: Acts as a versatile handle for bioconjugation and the creation of molecular probes for imaging and diagnostic applications.
• Process Chemistry & Scale-up: Provides a reliable and scalable building block for process research and development (PR&D) and pilot-scale manufacturing campaigns.

Basic Information

Product Name	(E)-2-(2-Fluorostyryl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	633327-38-5
Molecular Formula	C14H18BFO2
Molecular Weight	248.10 g/mol
Synonyms	2-(2-Fluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (E)-2-(2-Fluorovinyl)phenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; trans-2-(2-Fluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Fluorostyrylboronic acid pinacol ester; (2-Fluorostyryl)boronic acid pinacol ester; 2-Fluoro-β-styrylboronic acid pinacol ester; B-(2-Fluorostyryl)pinacolborane; 633327-38-5.
EINECS	Contact for details

Quality Control

Every batch of (E)-2-(2-Fluorostyryl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and isomeric integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (E/Z Ratio)	≥ 98:2 (E/Z)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.