Description

1,3,2-Dioxaborolane, 2-[(1E)-2-(3-Fluorophenyl)Ethenyl]-4,4,5,5-Tetramethyl- is a high-value, organoboron building block featuring a reactive vinyl group and a protected boronic ester moiety. This compound is essential for facilitating efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern synthetic chemistry. It is primarily needed by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing biaryl or styrenyl motifs with fluorine substitution.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science Research: Serves as a monomer or building block for creating functional polymers, organic electronic materials, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: The protected boronic ester functionality makes it a stable and effective partner for palladium-catalyzed carbon-carbon bond formation with aryl or vinyl halides.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and labeled compounds for imaging and diagnostic applications.
• Ligand and Catalyst Preparation: Acts as a versatile synthon for constructing sophisticated ligand systems used in homogeneous catalysis.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-[(1E)-2-(3-Fluorophenyl)Ethenyl]-4,4,5,5-Tetramethyl-
CAS No.	633327-36-3
Molecular Formula	C14H18BFO2
Molecular Weight	248.10 g/mol
Synonyms	(E)-2-(2-(3-Fluorophenyl)vinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-[(1E)-2-(3-Fluorophenyl)ethenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Fluorostyrylboronic acid pinacol ester; (3-Fluorostyryl)boronic acid pinacol ester; trans-3-Fluorostyrylboronic acid pinacol ester; (E)-3-Fluorostyrylboronic acid pinacol ester; 3-FluorostyrylBPin; CAS 633327-36-3
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane, 2-[(1E)-2-(3-Fluorophenyl)Ethenyl]-4,4,5,5-Tetramethyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and isomeric integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, and well-ventilated place. Keep away from heat, sparks, and open flame. Due to its sensitivity to moisture and oxidation, the container should be allowed to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (E/Z Ratio)	≥ 98:2 (E:Z)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.