Description

3-Chloro-4-Hydroxyphenylboronic Acid, Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides requiring specific chlorinated phenolic structures.
• Ligand & Catalyst Development: Serves as a starting material for creating specialized ligands and organometallic catalysts.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and sensors.
• Chemical Biology Probes: Useful for constructing molecular probes and bioconjugates due to its reactive boronate ester group.
• Custom Fine Chemical Production: Integral for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	3-Chloro-4-Hydroxyphenylboronic Acid, Pinacol Ester
CAS No.	629658-06-6
Molecular Formula	C₁₂H₁₆BClO₃
Molecular Weight	254.52 g/mol
Synonyms	3-Chloro-4-hydroxyphenylboronic acid pinacol ester; (3-Chloro-4-hydroxyphenyl)boronic acid pinacol ester; 2-(3-Chloro-4-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-4-hydroxybenzeneboronic acid pinacol ester; Pinacol (3-chloro-4-hydroxyphenyl)boronate; B-(3-Chloro-4-hydroxyphenyl)boronic acid pinacol ester; 629658-06-6; 3-Chloro-4-HBPin
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Hydroxyphenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance in GMP and ISO environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.