Description

2-(3-(Difluoromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound serves as a critical reagent in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and advanced organic materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key boronic ester precursor for forming carbon-carbon bonds in medicinal chemistry and material science.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of novel drug candidates, particularly those containing difluoromethylphenyl motifs.
• Agrochemical Research: Employed in the synthesis of advanced crop protection agents and herbicides.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands and organometallic catalysts.
• Polymer and Material Science: Incorporated into the synthesis of specialty polymers and organic electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems.

Basic Information

Product Name	2-(3-(Difluoromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	627525-89-7
Molecular Formula	C₁₃H₁₇BF₂O₂
Molecular Weight	266.09 g/mol
Synonyms	(3-(Difluoromethyl)phenyl)boronic acid pinacol ester; 2-[3-(Difluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-(Difluoromethyl)benzeneboronic acid pinacol ester; Pinacol [3-(difluoromethyl)phenyl]boronate; (3-Difluoromethylphenyl)boronic acid pinacol ester; Boronic acid, B-[3-(difluoromethyl)phenyl]-, 1,1-dimethylethyl ester; 3-Difluoromethylphenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(3-(Difluoromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and GC analysis, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the product should be handled under an inert atmosphere (e.g., nitrogen or argon) and kept free from moisture to maintain stability and purity. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.