Description

3-Iodo-4-Methylbenzyl Bromide CAS NO 626250-55-3 is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its bifunctional reactivity, featuring both a reactive benzyl bromide and an aryl iodide moiety, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a substituted benzyl or aryl iodide functional group.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the iodine atom serves as a handle for further functionalization.
• Material Science Research: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and halogen substituents.
• Cross-Coupling Reactions: Serves as a valuable substrate in palladium-catalyzed reactions such as Suzuki, Stille, and Sonogashira couplings to form new carbon-carbon bonds.
• Ligand and Catalyst Development: Utilized for synthesizing complex chelating ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Acts as a building block for creating tagged molecules and probes used in biochemical and diagnostic research.

Basic Information

Product Name	3-Iodo-4-Methylbenzyl Bromide
CAS No.	626250-55-3
Molecular Formula	C8H8BrI
Molecular Weight	310.96 g/mol
Synonyms	1-(Bromomethyl)-3-iodo-4-methylbenzene; (3-Iodo-4-methylphenyl)methyl Bromide; 4-Methyl-3-iodobenzyl Bromide; α-Bromo-3-iodo-4-methyltoluene; 3-Iodo-p-tolylmethyl Bromide; 3-Iodo-4-methylbenzylbromide; 626250-55-3; 4-Methyl-3-iodo-benzylbromide
EINECS	Contact for details

Quality Control

Every batch of 3-Iodo-4-Methylbenzyl Bromide is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your synthetic workflows. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as confirmed by techniques including HPLC, GC, NMR, and IR spectroscopy.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.