Description

Potassium Trimethoxy(Trifluoromethyl)Borate is an organoboron reagent featuring a trifluoromethyl group attached to a borate center. This compound is valued for its role as a versatile trifluoromethylating agent and a stable source of the nucleophilic trifluoromethyl anion equivalent in organic synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the efficient introduction of the metabolically stable trifluoromethyl group into complex molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the late-stage trifluoromethylation of drug candidates to enhance metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Development: Used in the synthesis of advanced pesticides and herbicides where the CF3 group improves biological activity and environmental persistence.
• Material Science Research: Employed in the creation of fluorinated organic materials, such as liquid crystals, polymers, and electronic chemicals with modified properties.
• Nucleophilic Trifluoromethylation: Serves as a shelf-stable, easy-to-handle source of the "CF3-" synthon for reactions with various electrophiles including carbonyl compounds, alkyl halides, and epoxides.
• Cross-Coupling Reactions: Can be utilized in transition-metal catalyzed cross-coupling processes to construct C-CF3 bonds.
• Asymmetric Synthesis: Applied in catalytic enantioselective trifluoromethylation reactions to produce chiral, non-racemic building blocks.

Basic Information

Product Name	Potassium Trimethoxy(Trifluoromethyl)Borate
CAS No.	626232-27-7
Molecular Formula	C4H9BF3KO3
Molecular Weight	212.02 g/mol
Synonyms	Potassium (Trifluoromethyl)trimethoxyborate; Trimethoxy(trifluoromethyl)borate Potassium Salt; Potassium Trifluoromethyltrimethoxyborate; Trifluoromethyltrimethoxyborate Potassium; Potassium Trifluoromethyl Borate Trimethyl Ester; K[BF3CF3(OMe)3]; (Trifluoromethyl)trimethoxyborate(1-) Potassium
EINECS	Contact for details

Quality Control

Our Potassium Trimethoxy(Trifluoromethyl)Borate is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, critical for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay (by NMR or titration), identity confirmation (by IR and NMR spectroscopy), and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical R&D and process chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) and protected from moisture. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (NMR/Titration)	≥95.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in common polar organic solvents (e.g., THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.