Description

n-Benzyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinamide is a high-purity boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. This compound is valued for its role in facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. It is primarily utilized by research institutions and pharmaceutical development companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting new therapeutic agents.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient formation of biaryl and heterobiaryl structures, which are prevalent scaffolds in many bioactive molecules.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the introduction of specific aromatic systems is required.
• Material Science: Employed in the creation of organic electronic materials, such as those used in OLEDs and semiconductors, due to its functional boronate group.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes for target identification and validation.

Basic Information

Product Name	n-Benzyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinamide
CAS No.	625470-38-4
Molecular Formula	C20H25BN2O3
Molecular Weight	352.24 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-benzylnicotinamide; N-Benzyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carboxamide; 3-Pyridinecarboxamide, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(phenylmethyl)-; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-benzylnicotinamide; B-3-((Benzylcarbamoyl)pyridin-5-yl)boronic acid pinacol ester; 625470-38-4; Benzyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinamide
EINECS	Contact for details

Quality Control

Our n-Benzyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.