Description

Methyl 2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is a high-value organoboron building block, specifically a boronic ester derivative, widely used in advanced synthetic chemistry. Its core value proposition lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of modern pharmaceutical and agrochemical manufacturing. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing biaryl and heterobiaryl scaffolds common in drug molecules.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific chlorinated biaryl structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of novel bidentate ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to synthesize tagged molecules or bioconjugates for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	Methyl 2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate
CAS No.	625470-33-9
Molecular Formula	C14H18BClO4
Molecular Weight	296.55 g/mol
Synonyms	2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester; Methyl 2-chloro-5-(pinacolatoboron)benzoate; 2-Chloro-5-(pinacolboronato)methyl benzoate; 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl benzoate; (2-Chloro-5-(methoxycarbonyl)phenyl)boronic acid pinacol ester; Methyl 5-borono-2-chlorobenzoate pinacol ester; 625470-33-9; Methyl 2-chloro-5-pinacolborylbenzoate
EINECS	Contact for details

Quality Control

Our Methyl 2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.