Description

1-(4-Bromo-2-Fluorophenyl)Ethanone is a high-purity fluorinated and brominated aromatic ketone, serving as a critical advanced intermediate in modern organic synthesis. Its unique halogenated structure makes it an indispensable building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating fluorinated aromatic cores essential in electronic materials for displays and lighting.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Functional Dye & Pigment Development: Utilized in synthesizing specialized dyes and pigments where halogenation alters light absorption and color fastness properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated intermediates.

Basic Information

Product Name	1-(4-Bromo-2-Fluorophenyl)Ethanone
CAS No.	625446-22-2
Molecular Formula	C8H6BrFO
Molecular Weight	217.04 g/mol
Synonyms	4'-Bromo-2'-fluoroacetophenone; 2-Fluoro-4-bromoacetophenone; 1-Acetyl-4-bromo-2-fluorobenzene; 4-Bromo-2-fluoroacetophenone; p-Bromo-o-fluoroacetophenone; (4-Bromo-2-fluorophenyl)ethan-1-one; Ethanone, 1-(4-bromo-2-fluorophenyl)-
EINECS	Contact for details

Quality Control

Every batch of 1-(4-Bromo-2-Fluorophenyl)Ethanone is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, GC, and NMR, is performed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.